Effect of Cadmium and Selenium on Hepatic Antioxidative Enzymes of Hamsters
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Abstract
This research aimed to study the toxicity of cadmium on hepatic antioxidant enzymes of hamsters and to investigate the protective effect of selenium on low dose cadmium administration on these enzyme systems. For acute toxicity studies, intraperitoneal administration of 1, 2.5 and 5 mg/kg of cadmium did not change selenium dependent glutathione peroxidase (Se-GPx) activity of males, whereas the enzyme activity decreased in females.
Cadmium at every doses of administration increased glutathion reductase (GR) activity in males but only at 2.5 mg/kg can increase this enzyme activity in females. Moreover catalase activity did not change in males but decreasd in females. There were no changes in hepatic glutatione levels of both genders. An administration of selenium with low dose cadmium (0.5 mg/kg) can decrease the hepatic cadmium levels in both sexes. Hepatic Se-GPx activities of male animals receiving either cadmium or selenium were not different from those of the control group. However, Se-GPx activity of male animals receiving cadmium plus selenium decreased. In contrast, hepatic Se-GPx activities of females increased in selenium alone or selenium plus cadmium groups. When compared to the control, there were no changes in GR activities of all studied male animals. But GR activities decreased in cadmium, selenium, and cadmium plus selenium treated animals. Catalase activity of selenium plus cadmium group was found to be lower than that of the control in both males and females. When compared to the control, GSH levels of all male treated animals did not change. Whereas in females, GSH levels increased in both selenium and selenium plus cadmium treated groups.
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