TY - JOUR AU - Jenraumjit, Rewadee AU - Tethanyawarakool, Vorrawee AU - Kongkhamboot, Hathaiphat AU - Piyatrakul, Namfon PY - 2018/12/26 Y2 - 2024/03/29 TI - Prescribing Pattern of Antipsychotic Long Acting Injections for the Treatment of Schizophrenia Patients in Suan Prung Psychiatric Hospital JF - Journal of the Psychiatric Association of Thailand JA - J Psychiatr Assoc Thailand VL - 63 IS - 4 SE - Original Articles DO - UR - https://he01.tci-thaijo.org/index.php/JPAT/article/view/162942 SP - 335-348 AB - <p>Objective : To study the prescribing pattern of antipsychotic long-acting injections: (LAIs) for the<br>treatment of schizophrenia patients in Suan Prung Psychiatric Hospital, Chiang Mai, Thailand<br>Method : A retrospective descriptive study was conducted to examine the database and<br>medical records of patients with schizophrenia. The study period was in October 1, 2014<br>to September 30, 2016. We collected data from the date patient initially received LAIs<br>and follow-up for 6-month period. Collected details of LAIs included type, dosage and<br>administration, concomitant oral antipsychotic drugs or other psychotropic medications,<br>and documented adverse drug reactions from LAIs by pharmacist. Analyzes were used for<br>descriptive statistics, percentage, mean, and standard deviation.<br>Result : All of the 100 samples were enrolled to the study. The majority of patients (61.0%)<br>receiving LAIs had non-adherence history. The most prescribed LAIs was fluphenazine<br>decanoate (89.0%), followed by haloperidol decanoate (5.0%), paliperidone palmitate<br>(5.0%), and risperidone microspheres (1.0%). More than 90.0% of the samples received<br>LAIs in combination with oral antipsychotic drugs (combination therapy). All patients<br>received combination therapy over a 6-month follow-up period. Adverse drug reactions<br>were documented in 17 patients and all of them were extrapyramidal symptoms. The most<br>documented symptoms were acute dystonia and parkinsonism. The results showed that 91.4%<br>of these patients received combination therapy.<br>Conclusion : The most prescribed LAIs for the treatment of schizophrenia patients in Suan<br>Prung Psychiatric Hospital was a first-generation antipsychotic drugs and was often prescribed<br>concomitant with oral antipsychotic drugs for long-term period. LAIs therapy should be reviewed<br>to develop a practice guideline in the context of Thailand. Eventually, to maximize benefit of<br>LAIs therapy to schizophrenia patients.</p> ER -