Comparison of the Effectiveness of Accelerated Hepatitis B Vaccination and Standard Hepatitis B Vaccination Programs in Pre-placement Examination of a Hospital Workers: A Study in the Teaching Hospital of the Northeastern Thailand

Abstract

Background and Objective: Health care workers were high risk group of HBV exposure. Accelerated hepatitis B vaccination can increase compliance in high risk group and rapidly activate immunity against HBV.  The objectives of this study were to compare effectiveness between accelerated hepatitis B vaccination and standard hepatitis B vaccination programs among a hospital employees.

Method: A decision analysis model was used to calculate the effectiveness of accelerated and standard hepatitis B vaccination programs. A group 78 hospital employees who received a standard hepatitis B vaccination program in 2014 and a group of 78 hospital employees who received an accelerated hepatitis B vaccination programs in 2015.

Results: Effectiveness of accelerated and standard hepatitis B vaccination programs were 83.4% and 76.4% respectively. Sensitivity analysis showed that different of effectiveness was 3.4-10.6%. Compliance of 1^st dose vaccination was the most influence factor of variation.

Conclusions: Accelerated hepatitis B vaccination programs were slightly more effective than standard hepatitis B vaccination programs. However, other factors are definitely accountable for this effectiveness; therefore inclusion of such factors will probably increase chance of effectiveness.