การวิเคราะห์ปัจจัยที่ส่งผลต่อความเป็นพิษของเซลล์ผิวหนังของแผ่นมาส์กหน้าจากไฟโบรอิน ไคโตซาน และไนอะซิน Analysis of Factors Influencing the Cytotoxicity of Fibroin-Chitosan-Niacin Facial Mask

Abstract

This research aims to analyze factors affecting cytotoxicity of facial masks fabricated from fibroin, chitosan and niacin by a lyophilized or freeze dry method applying a factorial experiment with center point.  The factors include levels of components used in the fabrication. In this study, fibroin was synthesized from Thai silkworm cocoons whereas niacin was synthesized from Hom-nin rice and chitosan from cuttlefish bone. From the results of the cytotoxicity tests, it was found that within the range studied the levels of niacin and interaction between chitosan and niacin significantly affected the cytotoxicity. The suitable levels of the components were 2 wt% chitosan and 5wt% niacin, resulting in good cell viability with the cell viability more than 100% within 24 hours.