Methylenetetrahydrofolate Reductase Gene and Vascular Thrombosis

Abstract

Background: Currently, the relationship between A1298C polymorphism of Methylenetetrahydrofolatereductase (MTHFR) gene and the risk of developing vascular thrombosis has not been reported in Thai people. Objective: To investigate the correlation between polymorphism of MTHFR gene and thrombosis in Thai people. Methods: MTHFR*A1298C gene polymorphism was analysed in blood samples derived from 200 Thai patients with thrombosis and 102 healthy Thai volunteers by polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP). Results: The genotypic variations in MTHFR*A1298C polymorphism were not significantly associated with the risk of developing thrombosis in Thai people [Odds ratio (95% confidence interval) = 1.059 (0.66- 1.71); p = 0.813]. Conclusion: The development of thrombosis in Thai people is not related to A1298C polymorphism of MTHFR gene.