Long-term effect of low-dose imatinib therapy for pulmonary hypertension due to chronic degenerative mitral valve disease in six dogs

Authors

  • Zi Ping Leong
  • Shinji Arita
  • Yoshiaki Hikasa

Keywords:

chronic degenerative mitral valve disease, low-dose imatinib, pulmonary hypertension

Abstract

Six dogs were diagnosed with pulmonary hypertension (PH) secondary to chronic degenerative mitral valve
disease (CDMVD) on echocardiography. Imatinib (3 mg/kg, every 24 hours, PO) was initiated without any changes to
the background therapy to treat the PH. Follow-up evaluations at 1, 3, 5 and 6 months revealed substantial clinical and
hemodynamic improvements. One dog showed deterioration after the imatinib withdrawal to necessitate a restart
therapy. No side effects were observed throughout the 6-month treatment course. Low-dose imatinib may provide a
promising treatment alternative for CDMVD-associated PH in dogs.

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Published

2018-09-20

How to Cite

Leong, Z. P., Arita, S., & Hikasa, Y. (2018). Long-term effect of low-dose imatinib therapy for pulmonary hypertension due to chronic degenerative mitral valve disease in six dogs. The Thai Journal of Veterinary Medicine, 48(3), 499–505. Retrieved from https://he01.tci-thaijo.org/index.php/tjvm/article/view/146588

Issue

Section

Clinical Reports